Stedies on Dextran

Effect of dextran sulphates on thrombin activity.

To clarify the action of dextran sulphate, a heparin analogue, in the clotting of fibrinogen by thrombin, determinations were carried out on the clotting activity, the release of fibrinopeptides from fibrinogen, and the hydrolytic activity of thrombin against a peptide chromogenic substrate in the absence or presence of antithrombin III (heparin cofactor). It was shown that dextran sulphate its...

Effects of dextran sulfate on aprotinin activity.

Dextran sulfate has an action on aprotinin activity similar to that seen with heparin: preincubation of dextran sulfate with aprotinin enhanced the inhibitory effect of aprotinin on the esterolytic activity of trypsin, but did not change the effect on the proteolytic activity of trypsin or on the esterolytic and proteolytic activities of chymotrypsin. The enhancing effects of heparin and dextra...

Effect of Dextran 40 on Urine Flow

Parenteral iron dextran therapy.

Parenteral iron therapy is indicated in patients with iron-deficiency anemia associated with conditions that interfere with the ingestion or absorption of oral iron. Replacement doses of iron required to replenish iron stores are based on body weight and the observed hemoglobin value. Methods of administering iron dextran are reviewed, including intramuscular and intravenous injections of the u...

Utilization of iron dextran.

The utilization of iron dextran was investigated in normal subjects, in patients with iron-deficiency anaemia, and in anaemias associated with rheumatoid arthritis, reticulosis, and uraemia. Utilization of iron for haemoglobin formation at 14 days was found to be depressed in patients with rheumatoid arthritis, reticulosis, and uraemia, but when a concomitant iron-deficiency anaemia was present...